Drug Interaction Checker
Select two or more medications to check for known interactions. This tool provides general guidance — always consult your veterinarian before combining medications.
Common Drug Interactions in Veterinary Medicine
The following are among the most commonly encountered drug interactions in companion animal medicine. This is not exhaustive — many other interactions exist.
| Drug A | Drug B | Interaction | Severity |
|---|---|---|---|
| NSAIDs (carprofen, meloxicam) | Corticosteroids (prednisone) | Increased risk of GI ulceration and bleeding | Severe |
| NSAIDs | Other NSAIDs | Do not combine — additive GI and renal toxicity | Severe |
| Fluoxetine (SSRI) | Tramadol | Risk of serotonin syndrome | Severe |
| Fluoxetine (SSRI) | Trazodone | Increased serotonergic effects — use with caution and vet monitoring | Moderate |
| ACE inhibitors (enalapril) | Potassium supplements | Risk of hyperkalemia | Moderate |
| Phenobarbital | Many drugs | Induces liver enzymes, may reduce effectiveness of other drugs | Moderate |
| Metronidazole | Phenobarbital | Phenobarbital may increase metronidazole clearance | Mild |
| Gabapentin | Sedatives/opioids | Additive sedation — dose adjustments may be needed | Moderate |
| Furosemide | ACE inhibitors | Often used together but risk of hypotension — monitor closely | Mild |
| Cyclosporine | Ketoconazole | Ketoconazole increases cyclosporine levels (sometimes used intentionally to reduce dose/cost) | Moderate |